Download Amiloride-Sensitive Sodium Channels: Physiology and by Dale J. Benos (Eds.) PDF

By Dale J. Benos (Eds.)

Sodium reabsorbing epithelia play an enormous function in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated by means of a number of various hormones. The sodium channels additionally play an important function in a couple of illness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range presents the 1st in-depth alternate of rules bearing on those sodium channels, their law and involvement in common and pathophysiological events. Key positive factors * Summarizes present kingdom of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal law of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents principles on sodium channels and affliction

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Extra info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

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Purves, R. , and MacKnight, A. D. C. (1988). Single channel recordings from the apical membrane of the toad urinary bladder epithelial cell. J. Membr. Biol. 106,157-172. Fuller, C. , Awayda, M. , Arrate, M. , Bradford, A. , Morns, R. , Canessa, C. , Rossier, B. , and Benos, D. J. (1995). Cloning of a bovine renal epithelial Na+ channel subunit. Am. J. Physiol. 269, C641-C654. Fuller, C. , Ismailov, I. , Berdiev, B. , Shlyonsky, V. , and Benos, D. J. (1996). Kinetic interconversion of rat and bovine homologs of the ct subunit of an amiloride-sensitive Na' channel by C-terminal truncation of the bovine subunit.

Welsh, unpublished). Mutation of Ser529to cysteine in y abolished inhibition by MTSEA (Fig. 5A). elegans degenerins, the site of neurodegeneration causing mutations. Modification of this cysteine by MTSEA may prevent channel inhibition by preventing further MTSEA molecules from entering the channel pore. When we coexpressed combinations of wild-type y and yS529c, MTSEA inhibited Na’ current less than would be expected from the proportion of wild-type subunits (Fig. 5A). This suggested that a single mutant y subunit 32 Peter M.

And Benos, D. J. (1988). Phosphorylation of a single subunit of the epithelial Na' channel protein following vasopressin treatment of A6 cells. J. B i d . Chem. 263, 13875-13879. , Canessa, C. , Shimkets. R. , Gautschi. , Lifton, R. , and Rossier, B. C. (1995). A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc. Natl. Acad. Sci. A. 92,5699-5703. , Schneeberger. , Lifton, R. , and Rossier, B. C. (1996).

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