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By MD Frank H. Netter

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B Nucleolus Figure 2-9B. Light microscopic appearance of an exocrine protein– secreting cell. H&E, ϫ750 Secretory granules Lumen Basophilic cytoplasm Site of Golgi Light microscopic views of exocrine secretory cells in sections are consistent with the structures that can be discerned in electron micrographs. The nucleus usually exhibits nucleoli and a considerable amount of euchromatin. The cytoplasm at the basal end of the cell is basophilic owing to the concentration of RER at this location. The position of the Golgi apparatus may be evident as a pale, unstained area of cytoplasm at the apical-facing edge of the nucleus.

This is not a common type of epithelium and has 28 UNIT 2 ■ Basic Tissues a very limited distribution. Occasionally, it can be found in the conjunctiva of the eye and in some large ducts of the exocrine glands. TRANSITIONAL EPITHELIUM is stratified epithelium, often referred to as urothelium, which lines the excretory channels leading from the kidney (renal calyces, ureters, bladder, and proximal segment of the urethra). It may contain four to six cell layers in the relaxed state. However, the histological appearance of the epithelium can change when stretched (Fig.

The apical (luminal) surface of these cuboidal cells is characterized by numerous short microvilli. C L I N I C A L CO RRELAT IO N C Active columnar cell Basal membrane D. Cui Connective tissue Hypothyroidism D. Cui Figure 3-5C. Hyperthyroidism. Hyperthyroidism is a condition characterized by the overproduction of thyroid hormone. In this condition, the follicular cells have changed from cuboidal cells to become columnar cells as a result of their high activity. Symptoms include nervousness, irritability, increased heart rate (tachycardia), increased perspiration, difficulty sleeping, muscle weakness, warm moist skin, trembling hands, and hair loss.

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